Carboidrati da fonti con un indice glicemico più elevato durante l'adolescenza: l'assunzione serale, piuttosto che mattutina, è rilevante per i marcatori di rischio del diabete di tipo 2 nella prima età adulta?

Background: This study investigated whether glycemic index (GI) or glycemic load (GL) of morning or evening intake and morning or evening carbohydrate intake from low- or higher-GI food sources (low-GI-CHO, higher-GI-CHO) during adolescence are relevant for risk markers of type 2 diabetes in young adulthood. Methods: Analyses included DO rtmund N utritional and A nthropometric L ongitudinally D esigned (DONALD) study participants who had provided at least two 3-day weighed dietary records (median: 7 records) during adolescence and one blood sample in young adulthood. Using multivariable linear regression analyses, estimated morning and evening GI, GL, low-GI-CHO (GI < 55) and higher-GI-CHO (GI ≥ 55) were related to insulin sensitivity ( N = 252), hepatic steatosis index (HSI), fatty liver index (FLI) (both N = 253), and a pro-inflammatory-score ( N = 249). Results: Morning intakes during adolescence were not associated with any of the adult risk markers. A higher evening GI during adolescence was related to an increased HSI in young adulthood ( p = 0.003). A higher consumption of higher-GI-CHO in the evening was associated with lower insulin sensitivity ( p = 0.046) and an increased HSI ( p = 0.006), while a higher evening intake of low-GI-CHO was related to a lower HSI ( p = 0.009). Evening intakes were not related to FLI or the pro-inflammatory-score (all p > 0.1). Conclusion: Avoidance of large amounts of carbohydrates from higher-GI sources in the evening should be considered in preventive strategies to reduce the risk of type 2 diabetes in adulthood.